Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry
نویسندگان
چکیده
منابع مشابه
Post-translational modifications of connexin26 revealed by mass spectrometry.
Gap junctions play important roles in auditory function and skin biology; mutations in the Cx26 (connexin26) gene are the predominant cause of inherited non-syndromic deafness and cause disfiguring skin disorders. Mass spectrometry (MS) was used to identify PTMs (post-translational modifications) of Cx26 and to determine whether they occur at sites of disease-causing mutations. Cx26 was isolate...
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Mass spectrometry is a widely used technique for protein identification and it has also become the method of choice in order to detect and characterize the post-translational modifications (PTMs) of proteins. Many software tools have been developed to deal with this complication. In this paper we introduce a new, free and user friendly online software tool, named POTAMOS Mass Spectrometry Calcu...
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Commentary It is not hard to imagine how mitochondria may play a role in epilepsy, given their diverse functions: ATP generation, calcium storage, cell death signaling, and mediators of oxidative stress. Thus, it is no surprise that mitochondrial dysfunction has been strongly linked to the pathogenesis of central nervous system disorders. For example, one form of early-onset Parkinson disease i...
متن کاملStrategies for shotgun identification of post-translational modifications by mass spectrometry.
The global identification of post-translationally modified proteins is a difficult challenge that is currently being addressed by many researchers in the field of mass spectrometry (MS)-based proteomics. The ability to identify thousands of proteins by shotgun-based strategies has made the mere idea of a global analysis of a particular protein modification seem reasonable. There has been much p...
متن کاملCharacterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry.
The nucleosome, the fundamental structural unit of chromatin, contains an octamer of core histones H3, H4, H2A, and H2B. Incorporation of histone variants alters the functional properties of chromatin. To understand the global dynamics of chromatin structure and function, analysis of histone variants incorporated into the nucleosome and their covalent modifications is required. Here we report t...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2007
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2007.03.012